IVPT - Full vs. Aliquot Sampling Techniques Study for Diclofenac Sodium and [¹⁴C]-Testosterone Using the Phoenix DB-6 Diffusion Testing System
Application Note  Request

Summary
This research study demonstrates that aliquot sampling is suitable for IVPT studies of Diclofenac Sodium Gel and [¹⁴C]-Testosterone Gel when using modern diffusion apparatus. This
is likely due to diffusion cell design innovations mentioned
above, which ensures receptor chamber and arm stem homogeneity, eliminating “apparent negative flux,” a phenomenon that industry hasn’t been able to explain. Although this study used Diclofenac Sodium Gel and [¹⁴C] -Testosterone Gel as the test articles, partial media replacement can be used with other
topical formulations.

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